The graphics are a wonderful mix of retro and modern, and the music is adorably and appropriately winsome. And then there's the gameplay, which I consider to be just as tight and well-tuned as the above-mentioned Gunpei Yokoi classic.
"I Am A Cave Story" by Annabelle Kennedy
That's not to suggest the game is faultless. It requires a bit more backtracking than I'd like, for instance, and it can be a smidge befuddling from time to time (i.e., I'm not always sure where I should go or what I should do next).
Neither of those negatives will keep me from completing Daisuke "Pixel" Amaya's action-adventure triumph, though--nor should they keep you from giving his charmingly challenging title a try.
See also: 'I can't wait to pop my Cave Story cherry'