It's called Dys4ia and, basically, it takes you through transgender game developer Anna Anthropy's rather tumultuous experiences with hormone replacement therapy.
I'm sure some will say it's not really a game, at least not in the traditional sense. My response to that: Anthropy's not exactly a traditional game developer, so what did you expect?
Anyway, I quite enjoyed my brief playthrough of Anthropy's latest Flash-based effort. I'm sure this will sound awfully odd, but it's kind of like an extremely linear WarioWare game, as each segment has you complete a (generally easy) task while reading a small bit of on-screen text.
Although such gameplay--if it can be called that--could be be boring in the wrong hands, in Anthropy's hands it's surprisingly compelling. Of course, it helps that she keeps things interesting by rarely calling on the player to complete the same "task" more than once.
As for Dys4ia's superficial aspects: Its pixel-based graphics are, as is seemingly always the case in an auntie pixelante game, superb, as is Liz Ryerson's spacey, new-age-ish soundtrack.
It only takes a few minutes to complete a single run-through of Dys4ia, so if you have the time and interest I'd highly recommend giving it a go (here) as soon as possible.
See also: Previous auntie pixelante posts