Actually, Aliens: Infestation will be my second-to-last must-buy DS game should Professor Layton and the Last Specter hit the streets after Sept. 30 (the former game's release date).
Regardless, I'll be picking up this WayForward-developed, Sega-published piece of software at some point this year. Why? Well, for starters, it's based on the Alien franchise. (Both Alien and its sequel are on my short list of all-time favorite films.) Second, it looks like a 16-bit game--which, in my mind, is pretty much always a good thing. Third, it plays like a Metroidvania title according to 1up.com's recent preview. (All of the above and more are on full display in this 13-minute video, by the way.)
The only aspect of Aliens: Infestation that I'm not completely sold on at this point is its cover art (above). I wouldn't say it's bad, but I wouldn't say it's menacing, either--and menacing is exactly what I expect from anything and everything related to this classic franchise.
See also: 'Curiosity of the day: Square's Aliens game' and '8-bit Ellen Ripley'