The following illustration makes me think a lot more art should be inspired by--or make use of imagery from--Mike Tyson's Punch-Out!!
Oh, and most of said art should be rather obtuse like the piece below.
Don't get me wrong, art that uses game imagery in a more straightforward manner--like this Soda Popinski illustration--is cool, too, but I generally prefer art that displays some creativity and individuality.
Speaking of which, the painting above was produced by deviantartist melonjaywalk, who shares that it "was done as a gift for a friend of mine based on some of her favorite things--which included movie reviews and The New Yorker."